Yes, although certain capabilities will be limited or unavailable when the camera isn't locked down on a tripod.
Tripod-free shooting with a DSLR
On DSLRs, Arsenal 2 offers a mirror-down AI mode for handheld shooting. In this mode, Arsenal constantly adjusts settings instead of changing them when you push the button on the app.
Since Arsenal 2 doesn't have access to the live view data in Handheld Mode (the mirror is down, not up), some of the attributes it looks at when choosing settings are only updated after you press the shutter. If the lighting conditions change, you'll need to take a photo to update Arsenal 2's suggestions.
Tripod-free shooting with a Mirrorless camera
On Mirrorless cameras, there's a hands-free mode that does all of the AI calculations and continually updates settings.
To enter Handheld Mode, with the device not powered on, briefly press the power button to turn it on. Arsenal 2's blue LEDs will animate during startup. The back LED bar will go off while the power button LED will remain on, indicating Arsenal 2 is ready. Once your Arsenal 2 has booted, double tap Arsenal 2’s power button.
*Fuji cameras do not support handheld mode
For more information on handheld shooting please read the following articles: